diff --git a/lib/Driver/SanitizerArgs.h b/lib/Driver/SanitizerArgs.h
index 2ca93bff35f51e7b71427e0e85d850df3181b80d..da6f4f6a9fb95dfa42ec713b0878780f95c0e463 100644
--- a/lib/Driver/SanitizerArgs.h
+++ b/lib/Driver/SanitizerArgs.h
@@ -94,8 +94,12 @@ class SanitizerArgs {
       CmdArgs.push_back(Args.MakeArgString("-fsanitize-memory-track-origins"));
 
     if (AsanZeroBaseShadow)
-      CmdArgs.push_back(Args.MakeArgString(
-          "-fsanitize-address-zero-base-shadow"));
+      CmdArgs.push_back(
+          Args.MakeArgString("-fsanitize-address-zero-base-shadow"));
+
+    // Workaround for PR16386.
+    if (needsMsanRt())
+      CmdArgs.push_back(Args.MakeArgString("-fno-assume-sane-operator-new"));
   }
 
  private:
diff --git a/test/Driver/fsanitize.c b/test/Driver/fsanitize.c
index 4899a2e75be5d850e6015925a7ade31712a88f7b..07e7f1e0f1d5cbf66979d3ac12aef754a66a980c 100644
--- a/test/Driver/fsanitize.c
+++ b/test/Driver/fsanitize.c
@@ -139,3 +139,6 @@
 
 // RUN: %clang -target x86_64-linux-gnu -fsanitize=address,leak -fno-sanitize=address %s -### 2>&1 | FileCheck %s --check-prefix=CHECK-SANA-SANL-NO-SANA
 // CHECK-SANA-SANL-NO-SANA: "-fsanitize=leak"
+
+// RUN: %clang -target x86_64-linux-gnu -fsanitize=memory %s -### 2>&1 | FileCheck %s --check-prefix=CHECK-MSAN
+// CHECK-MSAN: "-fno-assume-sane-operator-new"